PDBe 5air

X-ray diffraction
2.53Å resolution

Structural analysis of mouse GSK3beta fused with LRP6 peptide.


Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Glycogen synthase kinase-3 beta; Low-density lipoprotein receptor-related protein 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 430 amino acids
Theoretical weight: 47.82 KDa
Source organisms: Expression system: Spodoptera frugiperda
  • Canonical: Q9WV60 (Residues: 4-420; Coverage: 99%)
  • Canonical: O75581 (Residues: 1565-1575; Coverage: 1%)
  • nullnull
Gene names: Gsk3b, LRP6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: P212121
Unit cell:
a: 82.902Å b: 85.883Å c: 177.471Å
α: 90° β: 90° γ: 90°
R R work R free
0.215 0.212 0.26
Expression system: Spodoptera frugiperda