5agx

X-ray diffraction
2.24Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Apoptosis regulator Bcl-2; Bcl-2-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 166 amino acids
Theoretical weight: 19.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10415 (Residues: 1-34, 66-207; Coverage: 63%)
  • Canonical: Q07817 (Residues: 29-44; Coverage: 7%)
Gene names: BCL2, BCL2L, BCL2L1, BCLX
Sequence domains:
Apoptosis regulator Bcl-2; Bcl-2-like protein 1 Chain: B
Molecule details ›
Chain: B
Length: 166 amino acids
Theoretical weight: 19.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10415 (Residues: 1-34, 66-207; Coverage: 63%)
  • Canonical: Q07817 (Residues: 29-44; Coverage: 7%)
Gene names: BCL2, BCL2L, BCL2L1, BCLX
Sequence domains:
Bcl-2-like protein 11 Chains: C, D
Molecule details ›
Chains: C, D
Length: 22 amino acids
Theoretical weight: 2.71 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O43521 (Residues: 146-166; Coverage: 11%)
Gene names: BCL2L11, BIM

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P43212
Unit cell:
a: 86.054Å b: 86.054Å c: 108.739Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.188 0.245
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided