X-ray diffraction
2.9Å resolution

Crystal structure of the Helicase domain of human DNA polymerase theta in complex with AMPPNP


Function and Biology Details

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo tetramer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
DNA polymerase theta Chain: A
Molecule details ›
Chain: A
Length: 830 amino acids
Theoretical weight: 93.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: O75417 (Residues: 67-894; Coverage: 32%)
Gene names: POLH, POLQ
Sequence domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: I222
Unit cell:
a: 116.17Å b: 132.71Å c: 156.43Å
α: 90° β: 90° γ: 90°
R R work R free
0.22 0.217 0.264
Expression system: Spodoptera frugiperda