5a9q

Electron Microscopy
23Å resolution

Human nuclear pore complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero 304-mer (preferred)
Entry contents:
10 distinct polypeptide molecules
Macromolecules (10 distinct):
Nucleoporin Nup43 Chains: 0, 9, I, R
Molecule details ›
Chains: 0, 9, I, R
Length: 380 amino acids
Theoretical weight: 42.2 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8NFH3 (Residues: 1-380; Coverage: 100%)
Gene name: NUP43
Sequence domains: WD domain, G-beta repeat
Nuclear pore complex protein Nup160 Chains: 1, J, S, a
Molecule details ›
Chains: 1, J, S, a
Length: 1436 amino acids
Theoretical weight: 162.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q12769 (Residues: 1-1436; Coverage: 100%)
Gene names: KIAA0197, NUP120, NUP160
Sequence domains: Nucleoporin Nup120/160
Nucleoporin Nup37 Chains: 2, K, T, b
Molecule details ›
Chains: 2, K, T, b
Length: 326 amino acids
Theoretical weight: 36.75 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8NFH4 (Residues: 1-326; Coverage: 100%)
Gene name: NUP37
Sequence domains: WD domain, G-beta repeat
Nuclear pore complex protein Nup133 Chains: 3, C, L, U
Molecule details ›
Chains: 3, C, L, U
Length: 1156 amino acids
Theoretical weight: 129.11 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8WUM0 (Residues: 1-1156; Coverage: 100%)
Gene name: NUP133
Sequence domains: Non-repetitive/WGA-negative nucleoporin C-terminal
Nuclear pore complex protein Nup107 Chains: 4, D, M, V
Molecule details ›
Chains: 4, D, M, V
Length: 925 amino acids
Theoretical weight: 106.5 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P57740 (Residues: 1-925; Coverage: 100%)
Gene name: NUP107
Sequence domains: Nuclear pore protein 84 / 107
Nuclear pore complex protein Nup96 Chains: 5, E, N, W
Molecule details ›
Chains: 5, E, N, W
Length: 937 amino acids
Theoretical weight: 106.04 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P52948 (Residues: 881-1817; Coverage: 52%)
Gene names: ADAR2, NUP98
Sequence domains: Nuclear protein 96
Protein SEC13 homolog Chains: 6, F, O, X
Molecule details ›
Chains: 6, F, O, X
Length: 322 amino acids
Theoretical weight: 35.58 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P55735 (Residues: 1-322; Coverage: 100%)
Gene names: D3S1231E, SEC13, SEC13A, SEC13L1, SEC13R
Sequence domains: WD domain, G-beta repeat
Nucleoporin SEH1 Chains: 7, G, P, Y
Molecule details ›
Chains: 7, G, P, Y
Length: 360 amino acids
Theoretical weight: 39.7 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96EE3 (Residues: 1-360; Coverage: 100%)
Gene names: SEC13L, SEH1, SEH1L
Sequence domains: WD domain, G-beta repeat
Nuclear pore complex protein Nup85 Chains: 8, H, Q, Z
Molecule details ›
Chains: 8, H, Q, Z
Length: 656 amino acids
Theoretical weight: 75.11 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BW27 (Residues: 1-656; Coverage: 100%)
Gene names: NUP75, NUP85, PCNT1
Sequence domains: Nup85 Nucleoporin
Nuclear pore complex protein Nup155 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1391 amino acids
Theoretical weight: 155.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75694 (Residues: 1-1391; Coverage: 100%)
Gene names: KIAA0791, NUP155
Sequence domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 23Å
Relevant EMDB volumes: EMD-3103