Function and Biology

Discovery of NVP-CGM097 - a highly potent and selective MDM2 inhibitor undergoing phase 1 clinical trials in p53wt tumors: Hdm2 (MDM2) complexed with cpd2

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: regulation of cell cycle
Cellular component: nucleus

EC 2.3.2.27: RING-type E3 ubiquitin transferase

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
  • RING E3 ligase
  • Ubiquitin transferase RING E3

GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF02201
Domain description: SWIB/MDM2 domain
Occurring in:
  1. E3 ubiquitin-protein ligase Mdm2
The deposited structure of PDB entry 4zyi contains 1 copy of Pfam domain PF02201 (SWIB/MDM2 domain) in E3 ubiquitin-protein ligase Mdm2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003121
Domain description: SWIB/MDM2 domain
Occurring in:
  1. E3 ubiquitin-protein ligase Mdm2
IPR036885
Domain description: SWIB/MDM2 domain superfamily
Occurring in:
  1. E3 ubiquitin-protein ligase Mdm2
IPR016495
Domain description: p53 negative regulator Mdm2/Mdm4
Occurring in:
  1. E3 ubiquitin-protein ligase Mdm2

Structure domain

CATH CATH domain
1.10.245.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: MDM2
Homology: SWIB/MDM2 domain
Occurring in:
  1. E3 ubiquitin-protein ligase Mdm2
The deposited structure of PDB entry 4zyi contains 1 copy of CATH domain 1.10.245.10 (MDM2) in E3 ubiquitin-protein ligase Mdm2. Showing 1 copy in chain A.