PDBe 4zwe

X-ray diffraction
2.81Å resolution

Crystal structure of the dGTP-bound catalytic core of SAMHD1 T592V mutant

Source organism: Homo sapiens
Primary publication:
Impaired dNTPase Activity of SAMHD1 by Phosphomimetic Mutation of T592.
J. Biol. Chem. (2015)
PMID: 26294762

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 514 amino acids
Theoretical weight: 59.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9Y3Z3 (Residues: 113-626; Coverage: 82%)
Gene names: MOP5, SAMHD1
Sequence domains: HD domain
Structure domains: Hypothetical protein af1432

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 89.083Å b: 146.091Å c: 98.463Å
α: 90° β: 115.03° γ: 90°
R R work R free
0.21 0.208 0.248
Expression system: Escherichia coli