4zvw

X-ray diffraction
2.4Å resolution

Structure of apo human ALDH7A1 in space group C2

Released:
Source organism: Homo sapiens
Primary publication:
Structural Basis of Substrate Recognition by Aldehyde Dehydrogenase 7A1.
Biochemistry (2015)
PMID: 26260980

Function and Biology Details

Reactions catalysed:
(1a) (S)-2-amino-6-oxohexanoate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O (spontaneous)
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH
Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-aminoadipic semialdehyde dehydrogenase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 513 amino acids
Theoretical weight: 55.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49419 (Residues: 29-539; Coverage: 95%)
Gene names: ALDH7A1, ATQ1
Sequence domains: Aldehyde dehydrogenase family
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2
Unit cell:
a: 157.016Å b: 162.52Å c: 160.045Å
α: 90° β: 94.1° γ: 90°
R-values:
R R work R free
0.228 0.226 0.275
Expression system: Escherichia coli