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Structural mimicry of receptor interaction by antagonistic IL-6 antibodies

X-ray diffraction
2.93Å resolution
PDB entry 4zs7 coloured by chain, front view.
PDB entry 4zs7 coloured by chain, side view.
PDB entry 4zs7 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Interleukin-6 and IG-heavy chain and IG-light lambda chain
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Multimeric state: hetero trimer
Accessible surface area: 25933.27 Å2
Buried surface area: 5846.95 Å2
Dissociation area: 1,153.72 Å2
Dissociation energy (ΔGdiss): -7.86 kcal/mol
Dissociation entropy (TΔSdiss): 12.44 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-209243

Macromolecules

Interleukin-6
Chain: A
Length: 171 amino acids
Theoretical weight: 19.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05231 (Residues: 42-212; Coverage: 93%)
Gene names: IFNB2, IL6
Pfam: Interleukin-6/G-CSF/MGF family
InterPro:
CATH: Growth Hormone; Chain: A;
Interleukin-6 in PDB entry 4zs7, assembly 1, front view.
Interleukin-6 in PDB entry 4zs7, assembly 1, side view.
Interleukin-6 in PDB entry 4zs7, assembly 1, top view.
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Llama Fab fragment 68F2 heavy chain
Chain: H
Length: 222 amino acids
Theoretical weight: 23.82 KDa
Source organism: Lama glama
Expression system: Lama glama
InterPro:
CATH: Immunoglobulins
Llama Fab fragment 68F2 heavy chain in PDB entry 4zs7, assembly 1, front view.
Llama Fab fragment 68F2 heavy chain in PDB entry 4zs7, assembly 1, side view.
Llama Fab fragment 68F2 heavy chain in PDB entry 4zs7, assembly 1, top view.
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Llama Fab fragment 68F2 light chain
Chain: L
Length: 216 amino acids
Theoretical weight: 22.95 KDa
Source organism: Lama glama
Expression system: Lama glama
InterPro:
CATH: Immunoglobulins
Llama Fab fragment 68F2 light chain in PDB entry 4zs7, assembly 1, front view.
Llama Fab fragment 68F2 light chain in PDB entry 4zs7, assembly 1, side view.
Llama Fab fragment 68F2 light chain in PDB entry 4zs7, assembly 1, top view.
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