4zs7

X-ray diffraction
2.93Å resolution

Structural mimicry of receptor interaction by antagonistic IL-6 antibodies

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interleukin-6 Chain: A
Molecule details ›
Chain: A
Length: 171 amino acids
Theoretical weight: 19.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05231 (Residues: 42-212; Coverage: 93%)
Gene names: IFNB2, IL6
Structure domains: Growth Hormone; Chain: A;
Llama Fab fragment 68F2 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 222 amino acids
Theoretical weight: 23.82 KDa
Source organism: Lama glama
Expression system: Lama glama
Structure domains: Immunoglobulins
Llama Fab fragment 68F2 light chain Chain: L
Molecule details ›
Chain: L
Length: 216 amino acids
Theoretical weight: 22.95 KDa
Source organism: Lama glama
Expression system: Lama glama
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P2
Unit cell:
a: 46.55Å b: 92.86Å c: 84.63Å
α: 90° β: 103.93° γ: 90°
R-values:
R R work R free
0.264 0.261 0.293
Expression systems:
  • Escherichia coli
  • Lama glama