Function and Biology Details
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
- not assigned
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Serine/threonine-protein kinase LATS1 and Merlin (preferred)
PDBe Complex ID:
PDB-CPX-132065 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Merlin
Molecule details ›
Chains: A, B, C, D
Length: 324 amino acids
Theoretical weight: 38.04 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 324 amino acids
Theoretical weight: 38.04 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
- Canonical:
P46662 (Residues: 1-320; Coverage: 54%)
Sequence domains:
Structure domains:
Serine/threonine-protein kinase LATS1
Molecule details ›
Chains: E, F, G, H
Length: 32 amino acids
Theoretical weight: 3.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Length: 32 amino acids
Theoretical weight: 3.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: O95835 (Residues: 69-100; Coverage: 3%)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SSRF BEAMLINE BL17U
Spacegroup:
P212121
Expression system: Escherichia coli
