4zrj

X-ray diffraction
2.3Å resolution

Structure of Merlin-FERM and CTD

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Merlin Chain: A
Molecule details ›
Chain: A
Length: 320 amino acids
Theoretical weight: 37.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35240 (Residues: 1-320; Coverage: 54%)
Gene names: NF2, SCH
Sequence domains:
Structure domains:
Merlin Chain: B
Molecule details ›
Chain: B
Length: 90 amino acids
Theoretical weight: 10.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35240 (Residues: 506-595; Coverage: 15%)
  • Best match: P35240-2 (Residues: 506-579)
Gene names: NF2, SCH

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P212121
Unit cell:
a: 67.895Å b: 68.202Å c: 82.32Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.186 0.248
Expression system: Escherichia coli