PDBe 4zri

X-ray diffraction
2.7Å resolution

Crystal structure of Merlin-FERM and Lats2

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Merlin Chains: A, B
Molecule details ›
Chains: A, B
Length: 324 amino acids
Theoretical weight: 38.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35240 (Residues: 1-320; Coverage: 54%)
Gene names: NF2, SCH
Sequence domains:
Structure domains:
Serine/threonine-protein kinase LATS2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 32 amino acids
Theoretical weight: 3.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NRM7 (Residues: 68-99; Coverage: 3%)
Gene names: KPM, LATS2

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 62.962Å b: 100.549Å c: 65.03Å
α: 90° β: 105.85° γ: 90°
R-values:
R R work R free
0.229 0.227 0.27
Expression system: Escherichia coli