PDBe 4zo1

X-ray diffraction
3.22Å resolution

Crystal Structure of the T3-bound TR-beta Ligand-binding Domain in complex with RXR-alpha

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Thyroid hormone receptor beta Chain: X
Molecule details ›
Chain: X
Length: 252 amino acids
Theoretical weight: 28.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10828 (Residues: 210-461; Coverage: 55%)
Gene names: ERBA2, NR1A2, THR1, THRB
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chain: A
Molecule details ›
Chain: A
Length: 9 amino acids
Theoretical weight: 1.16 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 686-694; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2
Retinoic acid receptor RXR-alpha Chain: B
Molecule details ›
Chain: B
Length: 225 amino acids
Theoretical weight: 25.22 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P19793 (Residues: 231-455; Coverage: 49%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P3121
Unit cell:
a: 63.252Å b: 63.252Å c: 225.806Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.239 0.236 0.281
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided