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Crystal structure of the Fyn-SH3 domain in complex with the high affinity peptide APP12

X-ray diffraction
2.1Å resolution
PDB entry 4znx coloured by chain, front view.
PDB entry 4znx coloured by chain, side view.
PDB entry 4znx coloured by chain, top view.
Source organisms:
Assembly composition:
hetero octamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase Fyn and peptide
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Multimeric state: hetero octamer
Accessible surface area: 12083.53 Å2
Buried surface area: 7919.43 Å2
Dissociation area: 3,959.71 Å2
Dissociation energy (ΔGdiss): -4.27 kcal/mol
Dissociation entropy (TΔSdiss): 59.91 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-138974

Macromolecules

Tyrosine-protein kinase Fyn
Chains: A, B, C, D
Length: 58 amino acids
Theoretical weight: 6.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06241 (Residues: 84-141; Coverage: 11%)
Gene name: FYN
Pfam: SH3 domain
InterPro:
CATH: SH3 Domains
Tyrosine-protein kinase Fyn in PDB entry 4znx, assembly 1, front view.
Tyrosine-protein kinase Fyn in PDB entry 4znx, assembly 1, side view.
Tyrosine-protein kinase Fyn in PDB entry 4znx, assembly 1, top view.
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APP12
Chains: E, F, G, H
Length: 12 amino acids
Theoretical weight: 1.39 KDa
Source organism: synthetic construct
Expression system: Not provided
APP12 in PDB entry 4znx, assembly 1, front view.
APP12 in PDB entry 4znx, assembly 1, side view.
APP12 in PDB entry 4znx, assembly 1, top view.
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