PDBe 4zjw

X-ray diffraction
2.5Å resolution

RORgamma in complex with inverse agonist 16

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor ROR-gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 225 amino acids
Theoretical weight: 26.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P51449 (Residues: 265-487; Coverage: 43%)
Gene names: NR1F3, RORC, RORG, RZRG
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: C2
Unit cell:
a: 125.586Å b: 56.313Å c: 79.517Å
α: 90° β: 124.66° γ: 90°
R-values:
R R work R free
0.193 0.19 0.25
Expression system: Escherichia coli BL21(DE3)