› 4zjf

X-ray diffraction
2.6Å resolution

Crystal structure of GP1 - the receptor binding domain of Lassa virus

Released:
DOI: 10.2210/pdb4zjf/pdb
PDB entry 4zjf coloured by chain, front view.
PDB entry 4zjf coloured by chain, side view.
PDB entry 4zjf coloured by chain, top view.
Source organism: Lassa virus Josiah
Primary publication:
Molecular Mechanism for LAMP1 Recognition by Lassa Virus.
Cohen-Dvashi H, Cohen N, Israeli H, Diskin R
J Virol 89 7584-92 (2015)
PMID: 25972533

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140271 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Glycoprotein G1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 172 amino acids
Theoretical weight: 19.38 KDa
Source organism: Lassa virus Josiah
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P08669 (Residues: 75-237; Coverage: 33%)
Gene names: GP-C, GPC
Sequence domains: Arenavirus glycoprotein

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 8 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P21
Unit cell:
a: 49.62Å b: 86.47Å c: 109.48Å
α: 90° β: 92.81° γ: 90°
R-values:
R R work R free
0.212 0.209 0.241
Expression system: Trichoplusia ni

Quick links

Citations

12 review citations

Vaccine platforms for the prevention of Lassa fever.
Purushotham et al. (2019)
11 more

12 mentions without citation

Virus recognition of glycan receptors.
Thompson et al. (2019)
11 more