› 4zhg

X-ray diffraction
2.05Å resolution

Siderocalin-mediated recognition and cellular uptake of actinides

Released:
DOI: 10.2210/pdb4zhg/pdb
PDB 4zhg coloured by chain and viewed from the front.
PDB 4zhg coloured by chain and viewed from the side.
PDB 4zhg coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides.
Allred BE, Rupert PB, Gauny SS, An DD, Ralston CY, Sturzbecher-Hoehne M, Strong RK, Abergel RJ
Proc Natl Acad Sci U S A 112 10342-7 (2015)
PMID: 26240330

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neutrophil gelatinase-associated lipocalin Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 180 amino acids
Theoretical weight: 20.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P80188 (Residues: 21-198; Coverage: 100%)
Gene names: HNL, LCN2, NGAL
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

5 bound ligands:
Ligand AM 6 x AM
Ligand 4OL 6 x 4OL
Ligand GOL 2 x GOL
Ligand CL 6 x CL
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 107.733Å b: 117.693Å c: 121.225Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.195 0.217
Expression system: Escherichia coli BL21

Quick links

Citations

4 review citations

Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation.
Xiao et al. (2017)
3 more

1 mention without citation

Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides.
Allred et al. (2015)