PDBe 4zdr

X-ray diffraction
2.9Å resolution

Crystal structure of 14-3-3[zeta]-LKB1 fusion protein

Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
14-3-3 protein zeta/delta; Serine/threonine-protein kinase STK11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 266 amino acids
Theoretical weight: 30.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q15831 (Residues: 333-340; Coverage: 2%)
  • Canonical: P63104 (Residues: 1-234; Coverage: 96%)
  • nullnull
Gene names: LKB1, PJS, STK11, YWHAZ
Sequence domains: 14-3-3 protein
Structure domains: 14-3-3 domain

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: R32
Unit cell:
a: 130.262Å b: 130.262Å c: 264.96Å
α: 90° β: 90° γ: 120°
R R work R free
0.196 0.191 0.245
Expression system: Escherichia coli BL21(DE3)