X-ray diffraction
2.6Å resolution

Crystal structure of human IRE1 cytoplasmic kinase-RNase region - apo


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Serine/threonine-protein kinase/endoribonuclease IRE1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 416 amino acids
Theoretical weight: 47.76 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: O75460 (Residues: 562-977; Coverage: 43%)
Gene names: ERN1, IRE1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 79.401Å b: 78.971Å c: 86.045Å
α: 90° β: 97.41° γ: 90°
R R work R free
0.204 0.203 0.226
Expression system: Spodoptera frugiperda