› 4z4w

X-ray diffraction
1.8Å resolution

Crystal structure of GII.10 P domain in complex with 4.7mM fucose

Released:
DOI: 10.2210/pdb4z4w/pdb
PDB 4z4w coloured by chain and viewed from the front.
PDB 4z4w coloured by chain and viewed from the side.
PDB 4z4w coloured by chain and viewed from the top.
Source organism: Norovirus GII.10
Primary publication:
The sweet quartet: Binding of fucose to the norovirus capsid.
Koromyslova AD, Leuthold MM, Bowler MW, Hansman GS
Virology 483 203-208 (2015)
PMID: 25980740

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 315 amino acids
Theoretical weight: 34.51 KDa
Source organism: Norovirus GII.10
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q5F4T5 (Residues: 224-538; Coverage: 58%)
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand EDO 3 x EDO
Ligand FUL 1 x FUL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P21
Unit cell:
a: 65.29Å b: 79.344Å c: 69.576Å
α: 90° β: 100.78° γ: 90°
R-values:
R R work R free
0.156 0.155 0.191
Expression system: Escherichia coli BL21

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Citations

5 review citations

Glycopeptides and -Mimetics to Detect, Monitor and Inhibit Bacterial and Viral Infections: Recent Advances and Perspectives.
Behren et al. (2019)
4 more