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Structure of the MLL4 SET Domain

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 2.1.1.364: [Histone H3]-lysine(4) N-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(4)
Systematic name:
S-adenosyl-L-methionine:[histone H3]-L-lysine(4) N(6)-methyltransferase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00856
Domain description: SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase 2D
The deposited structure of PDB entry 4z4p contains 1 copy of Pfam domain PF00856 (SET domain) in Histone-lysine N-methyltransferase 2D. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001214
Domain description: SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase 2D
IPR046341
Domain description: SET domain superfamily
Occurring in:
  1. Histone-lysine N-methyltransferase 2D
IPR003616
Domain description: Post-SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase 2D

Structure domain

CATH CATH domain
2.170.270.10
Class: Mainly Beta
Architecture: Beta Complex
Topology: Beta-clip-like
Homology: SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase 2D
The deposited structure of PDB entry 4z4p contains 1 copy of CATH domain 2.170.270.10 (Beta-clip-like) in Histone-lysine N-methyltransferase 2D. Showing 1 copy in chain A.

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