› 4z33

X-ray diffraction
2.45Å resolution

Crystal structure of the syntenin PDZ1 and PDZ2 tandem in complex with the Frizzled 7 C-terminal fragment and PIP2

Released:
DOI: 10.2210/pdb4z33/pdb
PDB entry 4z33 coloured by chain, front view.
PDB entry 4z33 coloured by chain, side view.
PDB entry 4z33 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Egea-Jimenez AL, Gallardo R, Garcia-Pino A, Ivarsson Y, Wawrzyniak AM, Kashyap R, Loris R, Schymkowitz J, Rousseau F, Zimmermann P

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126343 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Syntenin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 166 amino acids
Theoretical weight: 18.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O00560 (Residues: 111-275; Coverage: 55%)
Gene names: MDA9, SDCBP, SYCL
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
Frizzled-7 Chains: C, D
Molecule details ›
Chains: C, D
Length: 6 amino acids
Theoretical weight: 605 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O75084 (Residues: 569-574; Coverage: 1%)
Gene name: FZD7

Ligands and Environments

3 bound ligands:
Ligand ACT 4 x ACT
Ligand GOL 2 x GOL
Ligand IP2 1 x IP2
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: P41212
Unit cell:
a: 71.744Å b: 71.744Å c: 126.36Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.181 0.239
Expression systems:
  • Escherichia coli BL21
  • Not provided

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