X-ray diffraction
1.78Å resolution

Function and Biology Details

Reaction catalysed:
Exonucleolytic cleavage of poly(A) to 5'-AMP
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
2',5'-phosphodiesterase 12 Chain: A
Molecule details ›
Chain: A
Length: 440 amino acids
Theoretical weight: 49.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q6L8Q7 (Residues: 155-609; Coverage: 72%)
Gene name: PDE12
Sequence domains: Endonuclease/Exonuclease/phosphatase family

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21
Unit cell:
a: 56.688Å b: 62.554Å c: 65.393Å
α: 90° β: 110.4° γ: 90°
R R work R free
0.166 0.164 0.201
Expression system: Escherichia coli BL21(DE3)