X-ray diffraction
2.3Å resolution

Crystal structure of TLR13-ssRNA13 complex


Function and Biology Details

Reaction catalysed:
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (3 distinct):
Toll-like receptor 13 Chains: A, D
Molecule details ›
Chains: A, D
Length: 709 amino acids
Theoretical weight: 81.34 KDa
Source organism: Mus musculus
Expression system: Insect cell expression vector pTIE1
  • Canonical: Q6R5N8 (Residues: 69-777; Coverage: 77%)
Gene name: Tlr13
Sequence domains:
DNA (5'-R(P*AP*CP*GP*GP*AP*AP*AP*GP*AP*CP*CP*CP*C)-3') Chains: B, C
Molecule details ›
Chains: B, C
Length: 13 nucleotides
Theoretical weight: 4.16 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 112.549Å b: 115.209Å c: 167.611Å
α: 90° β: 90° γ: 90°
R R work R free
0.191 0.191 0.244
Expression systems:
  • Insect cell expression vector pTIE1
  • Not provided