Structure analysis

Crystal structure of Deer prion protein complexed with POM1 FAB

X-ray diffraction
2.7Å resolution
Assemblies composition:
monomeric
hetero dimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Assemblies

Assembly 1
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Multimeric state: monomeric

Binding statistics and energies are not available for this assembly
Assembly 2 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 20800 Å2
Buried surface area: 3500 Å2
Dissociation area: 1,700 Å2
Dissociation energy (ΔGdiss): 15 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -27 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 135 amino acids
Theoretical weight: 15.96 KDa
Source organism: Odocoileus hemionus
Expression system: Escherichia coli
UniProt:
  • Canonical: P47852 (Residues: 124-231; Coverage: 47%)
Gene names: PRNP, PRP
InterPro:

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Chain: H
Length: 218 amino acids
Theoretical weight: 23.4 KDa
Source organism: Mus musculus
Expression system: Mus musculus
InterPro:
CATH: Immunoglobulins

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Chain: L
Length: 213 amino acids
Theoretical weight: 23.51 KDa
Source organism: Mus musculus
Expression system: Mus musculus
InterPro:
CATH: Immunoglobulins

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