4ypo

X-ray diffraction
1Å resolution

Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase in complex with Mg2+

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ketol-acid reductoisomerase (NADP(+)) Chains: A, B
Molecule details ›
Chains: A, B
Length: 333 amino acids
Theoretical weight: 36.13 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P9WKJ7 (Residues: 5-337; Coverage: 99%)
Gene names: MTV012.15c, Rv3001c, ilvC
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: C2
Unit cell:
a: 157.697Å b: 54.797Å c: 92.23Å
α: 90° β: 123.25° γ: 90°
R-values:
R R work R free
0.154 0.154 0.163
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'