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X-ray diffraction
2.6Å resolution

Crystal Structure of Stearoyl-Coenzyme A Desaturase 1

Released:
DOI: 10.2210/pdb4ymk/pdb
PDB 4ymk coloured by chain and viewed from the front.
PDB 4ymk coloured by chain and viewed from the side.
PDB 4ymk coloured by chain and viewed from the top.
Source organism: Mus musculus
Primary publication:
X-ray structure of a mammalian stearoyl-CoA desaturase.
Bai Y, McCoy JG, Levin EJ, Sobrado P, Rajashankar KR, Fox BG, Zhou M
OpenAccess logo Nature (2015)
PMID: 26098370

Function and Biology Details

Reaction catalysed: 
Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acyl-CoA desaturase 1 Chains: A, D
Molecule details ›
Chains: A, D
Length: 339 amino acids
Theoretical weight: 39.57 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P13516 (Residues: 24-355; Coverage: 94%)
Gene name: Scd1
Sequence domains: Fatty acid desaturase

Ligands and Environments

3 bound ligands:
Ligand ZN 4 x ZN
Ligand ST9 2 x ST9
Ligand MPG 2 x MPG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 77.061Å b: 113.766Å c: 141.698Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.203 0.235
Expression system: Trichoplusia ni

Quick links

Citations

10 review citations

Fatty acid recognition in the Frizzled receptor family.
Nile et al. (2019)
9 more

3 mentions without citation

Identification of a crucial amino acid implicated in the hydroxylation/desaturation ratio of CpFAH12 bifunctional hydroxylase.
Robin et al. (2019)
2 more