X-ray diffraction
2.6Å resolution

Crystal Structure of Stearoyl-Coenzyme A Desaturase 1


Function and Biology Details

Reaction catalysed:
Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Acyl-CoA desaturase 1 Chains: A, D
Molecule details ›
Chains: A, D
Length: 339 amino acids
Theoretical weight: 39.57 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
  • Canonical: P13516 (Residues: 24-355; Coverage: 94%)
Gene name: Scd1
Sequence domains: Fatty acid desaturase

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 77.061Å b: 113.766Å c: 141.698Å
α: 90° β: 90° γ: 90°
R R work R free
0.204 0.203 0.235
Expression system: Trichoplusia ni