› 4ykr

X-ray diffraction
1.61Å resolution

Heat Shock Protein 90 Bound to CS302

Released:
DOI: 10.2210/pdb4ykr/pdb
PDB entry 4ykr coloured by chain, front view.
PDB entry 4ykr coloured by chain, side view.
PDB entry 4ykr coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kang YN, Stuckey JA

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139817 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock protein HSP 90-alpha Chain: A
Molecule details ›
Chain: A
Length: 238 amino acids
Theoretical weight: 26.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07900 (Residues: 2-236; Coverage: 32%)
Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA
Sequence domains: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Structure domains: Histidine kinase-like ATPase, C-terminal domain

Ligands and Environments

2 bound ligands:
Ligand 4EP 1 x 4EP
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: I222
Unit cell:
a: 64.968Å b: 89.045Å c: 99.772Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.175 0.195
Expression system: Escherichia coli

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