PDBe 4ykn

X-ray diffraction
2.9Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase regulatory subunit alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Chain: A
Molecule details ›
Chain: A
Length: 1383 amino acids
Theoretical weight: 161.85 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P27986 (Residues: 318-615; Coverage: 41%)
  • Canonical: P42336 (Residues: 2-1068; Coverage: 100%)
Gene names: GRB1, PIK3CA, PIK3R1
Sequence domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P212121
Unit cell:
a: 84.667Å b: 118.191Å c: 190.281Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.202 0.247
Expression system: unidentified baculovirus