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Crystal structure of APC-ARM in complexed with Amer1-A2

X-ray diffraction
2.1Å resolution
PDB entry 4yjl coloured by chain, front view.
PDB entry 4yjl coloured by chain, side view.
PDB entry 4yjl coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Adenomatous polyposis coli protein and APC membrane recruitment protein 1
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Multimeric state: hetero dimer
Accessible surface area: 16499.62 Å2
Buried surface area: 3901.22 Å2
Dissociation area: 1,027.11 Å2
Dissociation energy (ΔGdiss): 9.78 kcal/mol
Dissociation entropy (TΔSdiss): 8.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150354
Assembly 2
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Assembly Name: Adenomatous polyposis coli protein and APC membrane recruitment protein 1
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Multimeric state: hetero dimer
Accessible surface area: 16350.31 Å2
Buried surface area: 3128.32 Å2
Dissociation area: 1,032.96 Å2
Dissociation energy (ΔGdiss): 9.61 kcal/mol
Dissociation entropy (TΔSdiss): 8.62 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150354
Assembly 3
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Assembly Name: Adenomatous polyposis coli protein and APC membrane recruitment protein 1
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Multimeric state: hetero dimer
Accessible surface area: 16487.23 Å2
Buried surface area: 3121.06 Å2
Dissociation area: 1,053.04 Å2
Dissociation energy (ΔGdiss): 9.09 kcal/mol
Dissociation entropy (TΔSdiss): 8.63 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150354
Assembly 4
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Assembly Name: Adenomatous polyposis coli protein and APC membrane recruitment protein 1
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Multimeric state: hetero dimer
Accessible surface area: 16740.75 Å2
Buried surface area: 3559.99 Å2
Dissociation area: 1,056.78 Å2
Dissociation energy (ΔGdiss): 10.57 kcal/mol
Dissociation entropy (TΔSdiss): 8.63 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150354
Assembly 5
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Assembly Name: Adenomatous polyposis coli protein and APC membrane recruitment protein 1
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Multimeric state: hetero dimer
Accessible surface area: 16699.37 Å2
Buried surface area: 3402.19 Å2
Dissociation area: 1,052.41 Å2
Dissociation energy (ΔGdiss): 9.39 kcal/mol
Dissociation entropy (TΔSdiss): 8.64 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150354
Assembly 6 (preferred)
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Assembly Name: Adenomatous polyposis coli protein and APC membrane recruitment protein 1
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Multimeric state: hetero dimer
Accessible surface area: 16710.73 Å2
Buried surface area: 2948.85 Å2
Dissociation area: 1,052.99 Å2
Dissociation energy (ΔGdiss): 9.57 kcal/mol
Dissociation entropy (TΔSdiss): 8.62 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150354

Macromolecules

Adenomatous polyposis coli protein
Chains: A, B, C, D, E, F
Length: 354 amino acids
Theoretical weight: 39.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P25054 (Residues: 407-751; Coverage: 12%)
Gene names: APC, DP2.5
Pfam:
InterPro:
CATH: Leucine-rich Repeat Variant
Adenomatous polyposis coli protein in PDB entry 4yjl, assembly 6, front view.
Adenomatous polyposis coli protein in PDB entry 4yjl, assembly 6, side view.
Adenomatous polyposis coli protein in PDB entry 4yjl, assembly 6, top view.
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APC membrane recruitment protein 1
Chains: G, H, I, J, K, L
Length: 13 amino acids
Theoretical weight: 1.52 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q5JTC6 (Residues: 496-508; Coverage: 1%)
Gene names: AMER1, FAM123B, WTX
APC membrane recruitment protein 1 in PDB entry 4yjl, assembly 6, front view.
APC membrane recruitment protein 1 in PDB entry 4yjl, assembly 6, side view.
APC membrane recruitment protein 1 in PDB entry 4yjl, assembly 6, top view.
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