PDBe 4yj5

X-ray diffraction
2.41Å resolution

Crystal structure of PKM2 mutant

Released:
Source organism: Homo sapiens
Entry authors: Liu J-S, Wu C-W, Wang W-C

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pyruvate kinase PKM Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 518 amino acids
Theoretical weight: 56.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P14618 (Residues: 14-531; Coverage: 98%)
Gene names: OIP3, PK2, PK3, PKM, PKM2
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P21
Unit cell:
a: 73.217Å b: 140.887Å c: 108.72Å
α: 90° β: 93.97° γ: 90°
R-values:
R R work R free
0.148 0.144 0.217
Expression system: Escherichia coli BL21(DE3)