› 4yho

X-ray diffraction
1.82Å resolution

Reversal Agent for Dabigatran

Released:
DOI: 10.2210/pdb4yho/pdb
PDB 4yho coloured by chain and viewed from the front.
PDB 4yho coloured by chain and viewed from the side.
PDB 4yho coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Structure-guided residence time optimization of a dabigatran reversal agent.
Schiele F, van Ryn J, Litzenburger T, Ritter M, Seeliger D, Nar H
MAbs 0 (2015)
PMID: 26047352

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
aDabi-Fab3 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 222 amino acids
Theoretical weight: 23.77 KDa
Source organism: Homo sapiens
Expression system: Cricetinae
Structure domains: Immunoglobulins
aDabi-Fab3 light chain Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.12 KDa
Source organism: Homo sapiens
Expression system: Cricetinae
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand 4CC 1 x 4CC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 60.278Å b: 78.089Å c: 93.372Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.18 0.21
Expression system: Cricetinae

Quick links

Citations

7 citation in other articles

Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology: First update 2016.
Kozek-Langenecker et al. (2017)
6 more

1 mention without citation

Structure-guided residence time optimization of a dabigatran reversal agent.
Schiele et al. (2015)