› 4yg0

X-ray diffraction
1.28Å resolution

Structural basis of glycan recognition in neonate-specific rotaviruses

Released:
DOI: 10.2210/pdb4yg0/pdb
PDB entry 4yg0 coloured by chain, front view.
PDB entry 4yg0 coloured by chain, side view.
PDB entry 4yg0 coloured by chain, top view.
Source organism: Human rotavirus A
Primary publication:
Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus.
Hu L, Ramani S, Czako R, Sankaran B, Yu Y, Smith DF, Cummings RD, Estes MK, Venkataram Prasad BV
Nat Commun 6 8346 (2015)
PMID: 26420502

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110369 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Outer capsid protein VP8* Chain: A
Molecule details ›
Chain: A
Length: 164 amino acids
Theoretical weight: 18.68 KDa
Source organism: Human rotavirus A
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: B6RGK2 (Residues: 64-225; Coverage: 21%)
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: BGC, GAL, NAG
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P212121
Unit cell:
a: 32.21Å b: 64.05Å c: 70.92Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.171 0.199
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Diversity in Rotavirus-Host Glycan Interactions: A "Sweet" Spectrum.
Ramani et al. (2016)
8 more

5 mentions without citation

Structural Basis of Glycan Recognition of Rotavirus.
Sun et al. (2021)
4 more