4yfd

X-ray diffraction
3.25Å resolution

Crystal structure PTP delta Ig1-Fn2 in complex with IL-1RAcP

Released:

Function and Biology Details

Reactions catalysed:
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-1 receptor accessory protein Chain: B
Molecule details ›
Chain: B
Length: 339 amino acids
Theoretical weight: 39.37 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q61730 (Residues: 21-351; Coverage: 60%)
Gene name: Il1rap
Sequence domains:
Structure domains: Immunoglobulins
Receptor-type tyrosine-protein phosphatase delta Chain: A
Molecule details ›
Chain: A
Length: 491 amino acids
Theoretical weight: 53.91 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q64487 (Residues: 21-511; Coverage: 26%)
Gene name: Ptprd
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P2
Unit cell:
a: 77.497Å b: 63.306Å c: 169.35Å
α: 90° β: 94.23° γ: 90°
R-values:
R R work R free
0.257 0.256 0.287
Expression system: Homo sapiens