PDBe 4ycg

X-ray diffraction
3.3Å resolution

Pro-bone morphogenetic protein 9

Released:
Source organisms:
Primary publication:
Structure of bone morphogenetic protein 9 procomplex.
Proc. Natl. Acad. Sci. U.S.A. (2015)
PMID: 25751889

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Growth/differentiation factor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 296 amino acids
Theoretical weight: 33.22 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q9WV56 (Residues: 23-318; Coverage: 73%)
Gene names: Bmp9, Gdf2
Sequence domains: TGF-beta propeptide
Growth/differentiation factor 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 110 amino acids
Theoretical weight: 12.1 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q9UK05 (Residues: 320-429; Coverage: 27%)
Gene names: BMP9, GDF2
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P3221
Unit cell:
a: 120.78Å b: 120.78Å c: 220.62Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.213 0.23
Expression system: Cricetulus griseus