PDBe 4ybh

X-ray diffraction
2.4Å resolution

Crystal structure of the human RAGE ectodomain (VC1C2 fragment) in complex with human S100A6

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Advanced glycosylation end product-specific receptor Chain: A
Molecule details ›
Chain: A
Length: 304 amino acids
Theoretical weight: 32.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15109 (Residues: 23-323; Coverage: 79%)
Gene names: AGER, RAGE
Sequence domains:
Structure domains: Immunoglobulins
Protein S100-A6 Chain: B
Molecule details ›
Chain: B
Length: 92 amino acids
Theoretical weight: 10.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06703 (Residues: 1-90; Coverage: 100%)
Gene names: CACY, S100A6
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: I222
Unit cell:
a: 75.98Å b: 112.53Å c: 139.89Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.233
Expression system: Escherichia coli BL21(DE3)