X-ray diffraction
2.33Å resolution

Crystal structure of COT kinase domain in complex with 5-(5-(1H-indol-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Mitogen-activated protein kinase kinase kinase 8 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 332 amino acids
Theoretical weight: 37.64 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P41279 (Residues: 66-395; Coverage: 71%)
Gene names: COT, ESTF, MAP3K8
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 147.978Å b: 85.113Å c: 85.964Å
α: 90° β: 91.06° γ: 90°
R R work R free
0.179 0.177 0.207
Expression system: Spodoptera frugiperda