› 4y7b

X-ray diffraction
1.79Å resolution

Factor Xa complex with GTC000441

Released:
DOI: 10.2210/pdb4y7b/pdb
PDB 4y7b coloured by chain and viewed from the front.
PDB 4y7b coloured by chain and viewed from the side.
PDB 4y7b coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Convery MA, Young RJ, Senger S, Hamblin JN, Chan C, Toomey JR, Watson NS

Function and Biology Details

Reaction catalysed: 
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Activated factor Xa heavy chain Chain: A
Molecule details ›
Chain: A
Length: 254 amino acids
Theoretical weight: 28.55 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00742 (Residues: 235-488; Coverage: 56%)
Gene name: F10
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Factor X light chain Chain: B
Molecule details ›
Chain: B
Length: 134 amino acids
Theoretical weight: 15.21 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00742 (Residues: 46-179; Coverage: 29%)
Gene name: F10
Sequence domains:
Structure domains: Laminin

Ligands and Environments

2 bound ligands:
Ligand CA 1 x CA
Ligand 44I 1 x 44I
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P212121
Unit cell:
a: 56.742Å b: 72.635Å c: 79.862Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.174 0.212

Quick links