X-ray diffraction
1.6Å resolution

Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, RC176, and manganese


Function and Biology Details

Reaction catalysed:
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic Chains: A, B
Molecule details ›
Chains: A, B
Length: 422 amino acids
Theoretical weight: 48.16 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q8IKG4 (Residues: 75-488; Coverage: 85%)
Gene names: DXR, PF14_0641, PF3D7_1467300
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P1
Unit cell:
a: 51.57Å b: 56.465Å c: 86.024Å
α: 104.11° β: 103.25° γ: 100.16°
R R work R free
0.178 0.177 0.206
Expression system: Escherichia coli BL21(DE3)