› › Structure analysis

Crystal structure of yeast N-terminal acetyltransferase (ppGpp) NatE in complex with a bisubstrate

X-ray diffraction
3.95Å resolution
PDB entry 4y49 coloured by chain, front view.
PDB entry 4y49 coloured by chain, side view.
PDB entry 4y49 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero tetramer
Accessible surface area: 56089.37 Å2
Buried surface area: 7617.99 Å2
Dissociation area: 760.44 Å2
Dissociation energy (ΔGdiss): -4.59 kcal/mol
Dissociation entropy (TΔSdiss): 17.35 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134098
Assembly 2
Download    3D Visualisation
Multimeric state: hetero tetramer
Accessible surface area: 55747.38 Å2
Buried surface area: 7776.86 Å2
Dissociation area: 798.49 Å2
Dissociation energy (ΔGdiss): -5.78 kcal/mol
Dissociation entropy (TΔSdiss): 17.35 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134098
Assembly 3
Download    3D Visualisation
Multimeric state: hetero tetramer
Accessible surface area: 55597.52 Å2
Buried surface area: 7701.75 Å2
Dissociation area: 747.14 Å2
Dissociation energy (ΔGdiss): -4.9 kcal/mol
Dissociation entropy (TΔSdiss): 17.32 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134098

Macromolecules

N-terminal acetyltransferase A complex subunit NAT1
Chains: A, G, M
Length: 854 amino acids
Theoretical weight: 99.08 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P12945 (Residues: 1-854; Coverage: 100%)
Gene names: AAA1, D2720, NAT1, YDL040C
Pfam: N-terminal acetyltransferase A, auxiliary subunit
InterPro:
N-terminal acetyltransferase A complex subunit NAT1 in PDB entry 4y49, assembly 1, front view.
N-terminal acetyltransferase A complex subunit NAT1 in PDB entry 4y49, assembly 1, side view.
N-terminal acetyltransferase A complex subunit NAT1 in PDB entry 4y49, assembly 1, top view.
Molecule details ›

Search similar proteins

N-terminal acetyltransferase A complex catalytic subunit ARD1
Chains: B, H, N
Length: 238 amino acids
Theoretical weight: 27.64 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P07347 (Residues: 1-238; Coverage: 100%)
Gene names: ARD1, YHR013C
Pfam: Acetyltransferase (GNAT) family
InterPro:
CATH: Aminopeptidase
N-terminal acetyltransferase A complex catalytic subunit ARD1 in PDB entry 4y49, assembly 1, front view.
N-terminal acetyltransferase A complex catalytic subunit ARD1 in PDB entry 4y49, assembly 1, side view.
N-terminal acetyltransferase A complex catalytic subunit ARD1 in PDB entry 4y49, assembly 1, top view.
Molecule details ›

Search similar proteins

N-alpha-acetyltransferase NAT5
Chains: C, I, O
Length: 176 amino acids
Theoretical weight: 19.75 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q08689 (Residues: 1-176; Coverage: 100%)
Gene names: NAT5, YOR253W
Pfam: Acetyltransferase (GNAT) family
InterPro:
CATH: Aminopeptidase
N-alpha-acetyltransferase NAT5 in PDB entry 4y49, assembly 1, front view.
N-alpha-acetyltransferase NAT5 in PDB entry 4y49, assembly 1, side view.
N-alpha-acetyltransferase NAT5 in PDB entry 4y49, assembly 1, top view.
Molecule details ›

Search similar proteins

Melanocyte-stimulating hormone alpha
Chains: E, K, Q
Length: 8 amino acids
Theoretical weight: 1.06 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01189 (Residues: 138-145; Coverage: 3%)
Gene name: POMC
Pfam: Corticotropin ACTH domain
Melanocyte-stimulating hormone alpha in PDB entry 4y49, assembly 1, front view.
Melanocyte-stimulating hormone alpha in PDB entry 4y49, assembly 1, side view.
Melanocyte-stimulating hormone alpha in PDB entry 4y49, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links