Function and Biology

M300V 3D polymerase mutant of EMCV

Source organism: Mengo virus
Biochemical function: RNA-dependent RNA polymerase activity
Biological process: viral RNA genome replication
Cellular component: not assigned

EC 3.6.4.13: RNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (RNA helix unwinding)
Alternative Name(s):
  • CSFV NS3 helicase
  • DBP2
  • DDX17
  • DDX25
  • DDX3
  • DDX3X
  • DDX3Y
  • DDX4
  • DDX5
  • DEAD-box RNA helicase
  • DEAD-box protein DED1
  • DEAH-box RNA helicase
  • DEAH-box protein 2
  • DED1
  • DbpA
  • Dex(H/D) RNA helicase
  • EIF4A helicase
  • EhDEAD1
  • EhDEAD1 RNA helicase
  • GRTH/DDX25
  • KOKV helicase
  • Mtr4p
  • NPH-II
  • Nonstructural protein 3 helicase
  • RHA
  • RNA helicase A
  • RNA helicase DDX3
  • RNA helicase Hera
  • RNA-dependent ATPase
  • TGBp1 NTPase/helicase domain
  • VRH1

EC 3.4.22.28: Picornain 3C

Reaction catalysed:
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Alternative Name(s):
  • 3C protease
  • 3C proteinase
  • Coxsackievirus 3C proteinase
  • Cysteine proteinase 3C
  • Foot-and-mouth protease 3C
  • Foot-and-mouth-disease virus proteinase 3C
  • Hepatitis A virus 3C proteinase
  • Picornavirus endopeptidase 3C
  • Poliovirus protease 3C
  • Poliovirus proteinase 3C
  • Protease 3C
  • Rhinovirus protease 3C
  • Rhinovirus proteinase 3C
  • Tomato ringspot nepovirus 3C-related protease

EC 2.7.7.48: RNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • 3D polymerase
  • PB1 proteins
  • PB2 proteins
  • Phage f2 replicase
  • Polymerase L
  • Q-beta replicase
  • RDRP
  • RNA nucleotidyltransferase (RNA-directed)
  • RNA replicase
  • RNA synthetase
  • RNA transcriptase
  • RNA-dependent RNA polymerase
  • RNA-dependent RNA replicase
  • RNA-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid replicase
  • Ribonucleic acid-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid-dependent ribonucleic acid polymerase
  • Ribonucleic replicase
  • Ribonucleic synthetase
  • Transcriptase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00680
Domain description: Viral RNA-dependent RNA polymerase
Occurring in:
  1. RNA-directed RNA polymerase
The deposited structure of PDB entry 4y2c contains 1 copy of Pfam domain PF00680 (Viral RNA-dependent RNA polymerase) in RNA-directed RNA polymerase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR043128
Domain description: Reverse transcriptase/Diguanylate cyclase domain
Occurring in:
  1. RNA-directed RNA polymerase
IPR007094
Domain description: RNA-directed RNA polymerase, catalytic domain
Occurring in:
  1. RNA-directed RNA polymerase
IPR001205
Domain description: RNA-directed RNA polymerase, C-terminal domain
Occurring in:
  1. RNA-directed RNA polymerase
IPR043502
Domain description: DNA/RNA polymerase superfamily
Occurring in:
  1. RNA-directed RNA polymerase

Structure domains

CATH CATH domains
3.30.70.270
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Alpha-Beta Plaits
Occurring in:
  1. RNA-directed RNA polymerase
The deposited structure of PDB entry 4y2c contains 1 copy of CATH domain 3.30.70.270 (Alpha-Beta Plaits) in RNA-directed RNA polymerase. Showing 1 copy in chain A.
1.20.960.20
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Mitochondrial Import Receptor Subunit Tom20; Chain A
Homology: Mitochondrial Import Receptor Subunit Tom20; Chain A
Occurring in:
  1. RNA-directed RNA polymerase
The deposited structure of PDB entry 4y2c contains 1 copy of CATH domain 1.20.960.20 (Mitochondrial Import Receptor Subunit Tom20; Chain A) in RNA-directed RNA polymerase. Showing 1 copy in chain A.