4y0j

Neutron Diffraction
2Å resolution

H/D exchanged human carbonic anhydrase II pH 6 room temperature neutron crystal structure.

Released:

Function and Biology Details

Reaction catalysed:
H(2)CO(3) = CO(2) + H(2)O
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 2 Chain: A
Molecule details ›
Chain: A
Length: 258 amino acids
Theoretical weight: 29.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00918 (Residues: 3-260; Coverage: 99%)
Gene name: CA2
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Alpha carbonic anhydrase

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Spacegroup: P21
Unit cell:
a: 42.75Å b: 41.68Å c: 72.95Å α: 90° β: 104.67° γ: 90°
R-values:
R R work R free 0.263 0.263 0.291
Expression system: Escherichia coli BL21(DE3)