› 4xyn

X-ray diffraction
2.55Å resolution

X-ray structure of Ca(2+)-S100B with human RAGE-derived W61 peptide

Released:
DOI: 10.2210/pdb4xyn/pdb
PDB 4xyn coloured by chain and viewed from the front.
PDB 4xyn coloured by chain and viewed from the side.
PDB 4xyn coloured by chain and viewed from the top.
Source organisms:
Primary publication:
Structural insights into the binding of the human receptor for advanced glycation end products (RAGE) by S100B, as revealed by an S100B-RAGE-derived peptide complex.
Jensen JL, Indurthi VS, Neau DB, Vetter SW, Colbert CL
Acta Crystallogr D Biol Crystallogr 71 1176-83 (2015)
PMID: 25945582

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
homo dimer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Advanced glycosylation end product-specific receptor Chain: P
Molecule details ›
Chain: P
Length: 15 amino acids
Theoretical weight: 1.65 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: Q15109 (Residues: 54-68; Coverage: 4%)
Gene names: AGER, RAGE
Protein S100-B Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 92 amino acids
Theoretical weight: 10.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04271 (Residues: 1-92; Coverage: 100%)
Gene name: S100B
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 8 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21212
Unit cell:
a: 68.785Å b: 86.684Å c: 66.534Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.203 0.254
Expression systems:
  • Not provided
  • Escherichia coli

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Citations

1 review citation

An oscillopathic approach to developmental dyslexia: From genes to speech processing.
Jiménez-Bravo et al. (2017)
6 other articles