4xyn

X-ray diffraction
2.55Å resolution

X-ray structure of Ca(2+)-S100B with human RAGE-derived W61 peptide

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
homo dimer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Advanced glycosylation end product-specific receptor Chain: P
Molecule details ›
Chain: P
Length: 15 amino acids
Theoretical weight: 1.65 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: Q15109 (Residues: 54-68; Coverage: 4%)
Gene names: AGER, RAGE
Protein S100-B Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 92 amino acids
Theoretical weight: 10.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04271 (Residues: 1-92; Coverage: 100%)
Gene name: S100B
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21212
Unit cell:
a: 68.785Å b: 86.684Å c: 66.534Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.203 0.254
Expression systems:
  • Not provided
  • Escherichia coli