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GRANULICELLA M. FORMATE DEHYDROGENASE (FDH) IN COMPLEX WITH NAD(+)

Source organism: Granulicella mallensis MP5ACTX8
Biochemical function: NAD binding
Biological process: formate catabolic process
Cellular component: cytosol

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EC 1.17.1.9: Formate dehydrogenase

Reaction catalysed:
Formate + NAD(+) = CO(2) + NADH
Systematic name:
Formate:NAD(+) oxidoreductase
Alternative Name(s):
  • FDH I
  • FDH II
  • Formate benzyl-viologen oxidoreductase
  • Formate dehydrogenase (NAD(+))
  • Formate hydrogenlyase
  • Formate-NAD(+) oxidoreductase
  • Formic acid dehydrogenase
  • Formic hydrogen-lyase
  • Hydrogenlyase
  • N-FDH
  • NAD(+)-dependent formate dehydrogenase
  • NAD(+)-formate dehydrogenase
  • NAD(+)-linked formate dehydrogenase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02826
Domain description: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Occurring in:
  1. Formate dehydrogenase
The deposited structure of PDB entry 4xye contains 2 copies of Pfam domain PF02826 (D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain) in Formate dehydrogenase. Showing 1 copy in chain A.

PF00389
Domain description: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Occurring in:
  1. Formate dehydrogenase
The deposited structure of PDB entry 4xye contains 2 copies of Pfam domain PF00389 (D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain) in Formate dehydrogenase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR033689
Domain description: NAD-dependent formate dehydrogenase
Occurring in:
  1. Formate dehydrogenase
IPR006140
Domain description: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
Occurring in:
  1. Formate dehydrogenase
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Formate dehydrogenase
IPR006139
Domain description: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Occurring in:
  1. Formate dehydrogenase

Structure domain

CATH CATH domain
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Formate dehydrogenase
The deposited structure of PDB entry 4xye contains 4 copies of CATH domain 3.40.50.720 (Rossmann fold) in Formate dehydrogenase. Showing 2 copies in chain A.

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