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Crystal structure of PDK1 in complex with ATP and the PIF-pocket ligand RF4

X-ray diffraction
1.4Å resolution
PDB entry 4xx9 coloured by chain, front view.
PDB entry 4xx9 coloured by chain, side view.
PDB entry 4xx9 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 3-phosphoinositide-dependent protein kinase 1
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Multimeric state: monomeric
Accessible surface area: 14359.29 Å2
Buried surface area: 1374.64 Å2
Dissociation area: 123.16 Å2
Dissociation energy (ΔGdiss): -1.28 kcal/mol
Dissociation entropy (TΔSdiss): 1.11 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127511

Macromolecules

3-phosphoinositide-dependent protein kinase 1
Chain: A
Length: 310 amino acids
Theoretical weight: 35.34 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O15530 (Residues: 50-359; Coverage: 56%)
Gene names: PDK1, PDPK1
Pfam: Protein kinase domain
InterPro:
CATH:
3-phosphoinositide-dependent protein kinase 1 in PDB entry 4xx9, assembly 1, front view.
3-phosphoinositide-dependent protein kinase 1 in PDB entry 4xx9, assembly 1, side view.
3-phosphoinositide-dependent protein kinase 1 in PDB entry 4xx9, assembly 1, top view.
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