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Crystal structure of the N-terminal domain of the human mitochondrial calcium uniporter

X-ray diffraction
1.5Å resolution
PDB entry 4xtb coloured by chain, front view.
PDB entry 4xtb coloured by chain, side view.
PDB entry 4xtb coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Calcium uniporter protein, mitochondrial
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Multimeric state: monomeric
Accessible surface area: 7094.12 Å2
Buried surface area: 393.91 Å2
Dissociation area: 196.96 Å2
Dissociation energy (ΔGdiss): -6.31 kcal/mol
Dissociation entropy (TΔSdiss): 3.48 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-185506

Macromolecules

Calcium uniporter protein, mitochondrial
Chain: A
Length: 123 amino acids
Theoretical weight: 14.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NE86 (Residues: 75-185; Coverage: 32%)
Gene names: C10orf42, CCDC109A, MCU
Pfam: Mitochondrial calcium uniporter
Calcium uniporter protein, mitochondrial in PDB entry 4xtb, assembly 1, front view.
Calcium uniporter protein, mitochondrial in PDB entry 4xtb, assembly 1, side view.
Calcium uniporter protein, mitochondrial in PDB entry 4xtb, assembly 1, top view.
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