› 4xox

X-ray diffraction
2.01Å resolution

Structure of beta-ketoacyl-ACP synthase I (FabB) from Vibrio Cholerae

Released:
DOI: 10.2210/pdb4xox/pdb
PDB entry 4xox coloured by chain, front view.
PDB entry 4xox coloured by chain, side view.
PDB entry 4xox coloured by chain, top view.
Source organism: Vibrio cholerae O1 biovar El Tor
Entry authors: Hou J, Grabowski M, Cymborowski M, Zheng H, Cooper DR, Anderson WF, Minor W, Center for Structural Genomics of Infectious Diseases (CSGID)

Function and Biology Details

Reaction catalysed: 
Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182146 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-oxoacyl-[acyl-carrier-protein] synthase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 404 amino acids
Theoretical weight: 42.73 KDa
Source organism: Vibrio cholerae O1 biovar El Tor
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7WUU8 (Residues: 1-403; Coverage: 100%)
Gene names: D6U24_00350, ERS013200_02557, ERS013201_02204, EYB64_02320, F0M16_13610, FLM02_03835, FXE67_13025, fabB
Sequence domains:
Structure domains: Peroxisomal Thiolase; Chain A, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P212121
Unit cell:
a: 54.756Å b: 88.654Å c: 167.258Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.15 0.149 0.177
Expression system: Escherichia coli

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