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Human OGT in complex with UDP-5S-GlcNAc and substrate peptide (RBL2)

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 2.4.1.255: Protein O-GlcNAc transferase

Reaction catalysed:
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine
Systematic name:
UDP-N-acetyl-D-glucosamine:protein-O-beta-N-acetyl-D-glucosaminyl transferase
Alternative Name(s):
  • O-GlcNAc transferase
  • O-linked N-acetylglucosaminyltransferase
  • OGTase
  • Protein O-linked beta-N-acetylglucosamine transferase
  • Uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF13414
Domain description: TPR repeat
Occurring in:
  1. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
The deposited structure of PDB entry 4xi9 contains 12 copies of Pfam domain PF13414 (TPR repeat) in UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit. Showing 3 copies in chain A.

PF13844
Domain description: Glycosyl transferase family 41
Occurring in:
  1. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
The deposited structure of PDB entry 4xi9 contains 4 copies of Pfam domain PF13844 (Glycosyl transferase family 41) in UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit. Showing 1 copy in chain A.

PF13424
Domain description: Tetratricopeptide repeat
Occurring in:
  1. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
The deposited structure of PDB entry 4xi9 contains 4 copies of Pfam domain PF13424 (Tetratricopeptide repeat) in UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR019734
Domain description: Tetratricopeptide repeat
Occurring in:
  1. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
IPR011990
Domain description: Tetratricopeptide-like helical domain superfamily
Occurring in:
  1. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
IPR029489
Domain description: O-GlcNAc transferase, C-terminal
Occurring in:
  1. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
IPR037919
Domain description: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit
Occurring in:
  1. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

Structure domains

CATH CATH domains
3.40.50.11380
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
The deposited structure of PDB entry 4xi9 contains 4 copies of CATH domain 3.40.50.11380 (Rossmann fold) in UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit. Showing 1 copy in chain A.
1.25.40.10
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology: Tetratricopeptide repeat domain
Occurring in:
  1. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
The deposited structure of PDB entry 4xi9 contains 8 copies of CATH domain 1.25.40.10 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat) in UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit. Showing 2 copies in chain A.
3.40.50.2000
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Glycogen Phosphorylase B;
Occurring in:
  1. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
The deposited structure of PDB entry 4xi9 contains 4 copies of CATH domain 3.40.50.2000 (Rossmann fold) in UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit. Showing 1 copy in chain A.
3.30.720.150
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Signal recognition particle alu RNA binding heterodimer, srp9/1
Homology: Signal recognition particle alu RNA binding heterodimer, srp9/1
Occurring in:
  1. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
The deposited structure of PDB entry 4xi9 contains 4 copies of CATH domain 3.30.720.150 (Signal recognition particle alu RNA binding heterodimer, srp9/1) in UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit. Showing 1 copy in chain A.

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