› 4xi3

X-ray diffraction
2.49Å resolution

Estrogen Receptor Alpha Ligand Binding Domain in Complex with Bazedoxifene

Released:
DOI: 10.2210/pdb4xi3/pdb
PDB 4xi3 coloured by chain and viewed from the front.
PDB 4xi3 coloured by chain and viewed from the side.
PDB 4xi3 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Fanning SW, Mayne CG, Toy W, Carlson K, Greene B, Nowak J, Walter R, Panchamukhi S, Tajhorshid E, Nettles KW, Chandarlapaty S, Katzenellenbogen J, Greene GL

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 243 amino acids
Theoretical weight: 27.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03372 (Residues: 306-548; Coverage: 41%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 29S 4 x 29S
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P1
Unit cell:
a: 53.575Å b: 59.165Å c: 94.144Å
α: 86.76° β: 75.36° γ: 63.03°
R-values:
R R work R free
0.218 0.215 0.268
Expression system: Escherichia coli BL21(DE3)

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