PDBe 4xev

X-ray diffraction
2.01Å resolution

Fusion of Pyk2-FAT domain with Leupaxin LD1 motif, complexed with Leupaxin LD4 peptide


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein-tyrosine kinase 2-beta Chains: A, D
Molecule details ›
Chains: A, D
Length: 167 amino acids
Theoretical weight: 18.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q14289 (Residues: 871-1005; Coverage: 13%)
Gene names: FAK2, PTK2B, PYK2, RAFTK
Structure domains: Nucleotidyltransferases domain 2
Leupaxin Chains: C, F
Molecule details ›
Chains: C, F
Length: 19 amino acids
Theoretical weight: 2.09 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: O60711 (Residues: 86-104; Coverage: 5%)
Gene names: LDLP, LPXN

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P21
Unit cell:
a: 52.078Å b: 79.235Å c: 53.227Å
α: 90° β: 117.62° γ: 90°
R R work R free
0.206 0.204 0.25
Expression systems:
  • Escherichia coli
  • Not provided